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Could a simple gel boost gum surgery results?

NCT ID NCT07529340

Disease control Sponsor: Universidade do Porto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

Gum recession exposes tooth roots, causing sensitivity and cosmetic concerns. Standard surgery (CAF + SCTG) covers the root, but healing can be slow. This trial tests whether adding a hyaluronic acid gel (hyaDENT BG®) to the surgery improves root coverage and recovery. Thirty-four adults with single gum recession defects will be randomly assigned to surgery with or without the gel, and followed for 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cross-linked hyaluronic acid gel (hyaDENT BG®)
What this could lead to
If it works, this could make gum surgery more effective at covering exposed roots and reduce pain or healing time.
What could go wrong
This is a small, early-stage trial with only 34 participants, so results may not apply to everyone. The gel is an add-on, not a replacement for surgery, and may not provide significant benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \- Age ≥ 18 years, in good general health (ASA I or II) * Presence of a single gingival recession defect classified as RT1 or RT2 * Recession depth ≥ 2 mm with identifiable cemento-enamel junction (CEJ) * Presence of at least 1 mm of keratinized tissue at the defect site * No active periodontal disease (probing depth ≤ 4 mm and no bleeding on probing at the selected tooth) * Full-Mouth Plaque Score (FMPS ≤ 20%) and Full-Mouth Bleeding Score (FMBS ≤ 20%) * Vital tooth without caries, cervical lesions, or defective restorations * Good oral hygiene and motivation to maintain plaque control * Ability and willingness to comply with study procedures * Signed informed consent Exclusion Criteria: * Uncontrolled systemic diseases (e.g., uncontrolled diabetes, severe cardiovascular disease, immunodeficiency) * Pregnant or breastfeeding women * Autoimmune diseases or immunosuppressive therapy * Known hypersensitivity to hyaluronic acid * Heavy smokers (\>10 cigarettes/day) or recent tobacco use * Active periodontal disease at the study site * Caries, root fractures, endodontic lesions, or defective restorations at the study tooth * Previous mucogingival surgery at the study site * Recent use of antibiotics, corticosteroids, or anti-inflammatory drugs * Coagulation disorders or anticoagulant therapy contraindicating surgery * Hormonal disorders affecting wound healing * Acute oral infections * Any condition that may interfere with study participation or follow-up

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Conditions

The condition(s) this trial relates to.

gingival recession

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingival recession, mucogingival surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CEPI - Clinical Center for Periodontology and Implantology

    Porto, Porto District, 4350-110, Portugal

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