Home leg exercises may rewire the brain after severe stroke

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Single, monohemispheric stroke * Chronic stroke (\> 6 months prior) * Severe stroke (Fugl-Meyer Lower Extremity motor scale score \< 21 or 6 Minute Walk Test distance \< 300m) Exclusion Criteria: * Use of anti-spasticity medications * Existence of other neurological disorders * Have brainstem or cerebellar lesions. * Mini-Mental State Examiniation score of \<21, to ensure participants have the cognitive capacity to consent and can understand instructions both in-person and during remote supervision. * Non-English-speaking individuals * Bone, joint or soft tissue injury * Uncontrolled medical conditions (such as uncontrolled hypertension, untreated cardiac disease, or untreated pulmonary disease) * Unable to see the tablet and zoom screen * Unable to move non-paretic ankle (\< 5 degrees of ankle ROM) * Fugl-Meyer Lower Extremity sensory scale score \< 6 TMS exclusion criteria * Previous adverse reaction to TMS * Skull abnormalities or fractures * Concussion within the prior 6 months * Unexplained, recurring headaches * Implanted cardiac pacemaker * Metal implants in the head or face * History of seizures or epilepsy * Use of medications that could alter cortical excitability or increase risk of seizure (e.g., antidepressants, antipsychotics, anxiolytics, anticonvulsants) * Current pregnancy PNS exclusion criteria * Skin hypersensitivity at any sites of stimulation, including the scalp, thoracolumbar spine, and peripheral limbs * History of contact dermatitis at any of the sites of stimulation * History of allodynia and/or hyperalgesia * Active skin infection * Skin lesions * Deep vein thrombosis * Any other skin or scalp condition that could be aggravated by stimulation * Implanted electronic, metallic, or highly conductive devices near site of stimulation that cannot be removed without permission from a health professional