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New transplant matching method could predict organ failure

NCT ID NCT07269275

Knowledge-focused Sponsor: Paris Translational Research Center for Organ Transplantation Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at over 5,500 kidney transplant patients to see if a more detailed way of matching donors and recipients—called HLA eplet mismatches—can better predict long-term transplant failure than standard methods. The goal is to improve how doctors assess risk and manage patients after a kidney transplant. No new treatment was tested; instead, researchers analyzed existing data to see if this refined matching approach adds value.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a more accurate way to predict kidney transplant failure, helping doctors personalize care and improve transplant longevity.
What could go wrong
This is an observational study, not a treatment trial. It may not prove that eplet mismatches are better than current methods, and results may not change clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

5,525 people

The number who actually took part.

Started

Jan 2023

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Kidney transplant recipients from seven European referral centers

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Living or deceased donor kidney recipients transplanted after 2004 * Kidney recipients older than 18 years of age * Kidney recipients with available HLA genotyping data Exclusion Criteria: * Combined transplantation

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Kidney transplant failure

Contacts and locations

Locations

  • Paris Translational Research Center for Organ Transplantation

    Paris, France

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