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HIV and ageing: new study reveals health challenges for those over 50

NCT ID NCT01737047

Knowledge-focused Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study followed over 1,300 people with HIV in England and Ireland to understand how ageing affects their health. Researchers compared older HIV-positive adults (over 50) with younger HIV-positive adults and HIV-negative older adults. The goal was to identify common medical issues like aches and pains, and see how HIV medications work differently with age. Results could help shape future care guidelines for this growing population.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better monitor and treat older people with HIV, potentially improving future treatment guidelines.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly lead to new therapies. Results may not apply to all populations or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,377 people

The number who actually took part.

Started

Apr 2013

Finished

Mar 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

HIV positive over 50 years HIV positive between 18 and 50 years HIV negative over 50 years White Black african

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Older HIV-positive cohort (n=1000): * documented HIV infection * age \>50 years at study entry * self defined white or black African ethnicity * likely route of HIV acquisition via sexual exposure Either by male to male exposure if white or by heterosexual exposure if white or black African * able to comprehend study patient information leaflet -Younger HIV-positive cohort (n=500): * documented HIV infection * age \<50 at study entry\* * self defined white or black African ethnicity * likely route of HIV acquisition via sexual exposure Either by male to male exposure if white or by heterosexual exposure if white or black African. * able to comprehend study patient information leaflet * this group will comprise of at least 150 subjects in each of the following age groups: 20-29, 30-39, 40-49 years. Recruitment will be monitored by the Study Monitoring Team. HIV-negative cohort (n=500): * documented negative HIV test at screening * age \>50 years at study entry * self defined white or black African ethnicity * registered with a General Practitioner and gives permission for contact with that General Practitioner. Exclusion Criteria: * in the opinion of the investigator, those unable or unwilling to comply with the requirements of the study * life expectancy less than 6 months

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Conditions

The condition(s) this trial relates to.

HIV infectious disease HIV Seropositivity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ageing HIV positive

Contacts and locations

Locations

  • Chelsea and Westminster Hospital

    London, SW10 9NH, United Kingdom

  • Homerton University Hospital NHS Foundation Trust

    London, E9 6SR, United Kingdom

  • Kings College Hospital NHS Trust

    London, SE5 9RJ, United Kingdom

  • Royal Free Hospital

    London, NW3 2QG, United Kingdom

  • Royal Sussex County Hospital

    Brighton, Sussex, BN2 5BE, United Kingdom

  • St Marys Hospital NHS Trust

    London, W2 1NY, United Kingdom

  • University College Dublin School of Medicine and Medical Sciences, Mater Misericordiae University Hospital

    Dublin, 7, Ireland

  • University College NHS Trust

    London, WC1E 6JB, United Kingdom

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