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New combo therapy aims to free ventilator patients faster

NCT ID NCT05932134

Disease control Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding a high-protein diet, core muscle exercises, and neuromuscular electrical stimulation helps patients who have been on a breathing machine for over 21 days wean off it. One hundred participants received these treatments alongside usual care. The main goal was to see if more patients could breathe without the ventilator for five straight days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high protein diet, core muscle rehabilitation, and neuromuscular electrical stimulation
What this could lead to
If successful, this combination could help patients on long-term ventilators wean off faster, reducing hospital stays and complications.
What could go wrong
This is a small, completed trial without a randomized phase. Results may not apply to all patients, and the interventions require significant effort and resources.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

100 people

The number who actually took part.

Started

Sep 2023

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. age ≥ 20 year old 2. using mechanical ventilator for more than 21 days (including patients under tracheostomy or endotracheal tube) 3. stable clinical condition, without using inotropic agent (arterial blood gas pH : 7.35-7.45, PaO2≥60 mm Hg at FiO2 40%, absence of signs and symptoms of uncontrolled infection, and hemodynamic stability) 4. maximal inspiratory pressure (MIP) \< 30mmHg 5. under enteral nutrition (EN) via NG tube. Exclusion Criteria: 1. Acute infection and sepsis (fever up to 38.5 degree) 2. Severe neuromuscular disease, or uncontrolled epilepsy 3. Bony fracture or DVT history 4. Wound over the abdomen 5. Congestive heart failure with EF \< 40% or using pacemaker 6. BMI\>35 kg/M2, or severe edema 7. Patients with hepatic failure, rapid progressed malignancy, or pregnancy were also excluded. 8. Under parenteral nutrition (PN) 9. Use pacemaker

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Conditions

The condition(s) this trial relates to.

Protein Deficiency protein S deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Prolonged mechanical ventilation Protein deficiency

Contacts and locations

Locations

  • Department of Thoracic Medicine, Chang Gung Memorial Hospital

    Taoyuan, 333, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.