Olive oil showdown: could High-Phenolic EVOO beat belly fat?
NCT ID NCT07445503
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a high-phenolic olive oil can improve metabolic health better than a low-phenolic version. Over 8 weeks, 80 adults with overweight/obesity and metabolic issues will consume one of the two oils. Researchers will measure changes in blood fats, blood pressure, blood sugar, and inflammation markers.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2025
- Expected to finish
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May 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult men and women 18-80 years of age, * Overweight/obesity (body mass index \> 25 or waist circumference \>94 cm for males and \>80 cm for females), and * The presence of at least one of the following metabolic abnormality: (1) triglyceride level ≥150 mg/dL or HDL cholesterol ≤40 mg/dL in men and ≤50 mg/dL in women; (2) increased blood pressure ≥ 130/85 mm Hg; (3) elevated fasting blood sugar ≥100 mg/dL; (4) standardized drug treatment regimen, and * Provided signed informed consent for participation. Exclusion Criteria: * Concomitant acute or chronic disease (e.g., infection, cancer, chronic heart failure, kidney disease, autoimmune diseases like rheumatoid arthritis, inflammatory bowel diseases, Hashimoto), * Untreated diabetes, * Women at pregnancy or lactation, * Individuals with psychiatric or mental disorder, * Any use of antioxidant-phytochemical rich supplement, anti-, pre- or probiotics pre-intervention, * Drug and/or alcohol abuse, * Those who did not consent or were unable to provide consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Antikalamos Facilities of University of Peloponnese
RECRUITINGKalamata, 24100, Greece
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