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Ancient herbs face off against metformin in diabetes trial

NCT ID NCT07279909

Disease control Sponsor: Hamdard University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests a capsule made from four traditional anti-diabetic herbs (Syzygium cumini, bitter melon, Wrightia tinctoria, and Gymnema sylvestre) in 500 adults with type 2 diabetes. Participants take either the herbal capsule or the standard drug metformin three times daily for six months. The study aims to see if the herbal blend can lower blood sugar and HbA1c as effectively as metformin, while also checking safety.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Polyherbal capsule (Syzygium cumini, bitter melon, Wrightia tinctoria, Gymnema sylvestre)
What this could lead to
If it works, this could offer a natural, plant-based option to help control blood sugar in type 2 diabetes, possibly as an alternative or add-on to standard drugs like metformin.
What could go wrong
This is a single trial with 500 people, and results may not apply to everyone. Herbal products can vary in potency, and the combination hasn't been tested before, so safety and effectiveness are still unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

500 people

The number who actually took part.

Started

Mar 2024

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients having Type II Diabetes Mellitus. * Patients agree willingly to use study medicine throughout the study * Patients having raised FBS above 120 mg/dl and HbA1C level 6.7 or above. * Patients over 30 years of age. * Patients of both genders will be included in the study. Exclusion Criteria: * Patients who do not agree willingly to participate in research. * Patients having history of any chronic organ failure. * Patients having history of any amputation. * Patients having history of treated or diagnosed cancer of any organ. * Pregnant and lactating mothers. * Patients who are having brittle Diabetes * Known under treatment cases of psychiatric disorders

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Conditions

The condition(s) this trial relates to.

Diabetes Mellitus, Experimental diabetes mellitus, non-human animal type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ability of experimental drug to lower HbA1c compare to metformin Diabetes mellitus, experimental Diabetes type 2 HbA1c Urinary glucose

Contacts and locations

Locations

  • Mehboob Faryal Diagnostic Center

    Karachi, Sindh, 74700, Pakistan

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