Heart wave analysis may reveal hidden recovery in lung disease patients
NCT ID NCT07522203
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a special heart pressure wave test can better track recovery in adults with chronic blood clots in the lungs (CTEPH) who are getting a procedure to open blocked arteries (balloon pulmonary angioplasty). Researchers will measure walking distance, heart function, and quality of life before and after treatment. The goal is to see if these new measurements are more useful than standard tests for showing true improvement.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2026
- Expected to finish
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May 2028
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study will include consecutive patients with a confirmed diagnosis of CTEPH according to current guidelines who are clinical candidates for balloon pulmonary angioplasty (BPA).
- Ages
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18 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18-85 years. Confirmed diagnosis of CTEPH by a multidisciplinary CTEPH team and deemed eligible for BPA. Hemodynamics compatible with pre-capillary PH according to current guidelines, as assessed by RHC (Right Heart Catheterization). Technically inoperable CTEPH or persistent/recurrent PH following PEA (Pulmonary Endarterectomy). Written informed consent. Exclusion Criteria: * Predominant diagnosis of PH other than CTEPH or concomitant severe parenchymal lung disease. Active infection, uncontrolled systemic disease, active malignancy, or life expectancy \< 12 months. Pregnant or lactating patients. Advanced renal failure (e.g., eGFR \< 30 \\text{ mL/min/1.73 m\^2}) or contraindications to contrast media (per institutional routine). Inadequate image quality precluding reliable echocardiographic analysis. Pressure tracings with significant artifacts hindering analysis or uncontrolled arrhythmia (e.g., atrial fibrillation with rapid ventricular response). Decompensated or hemodynamically unstable patients. Any other condition deemed clinically unsuitable by the investigator.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Istanbul Mehmet Akif Ersoy Educational and Training Hospital
RECRUITINGIstanbul, 34303, Turkey (Türkiye)
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Other studies related to the condition(s) this trial covers.
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- BREATHE-PH study aims to unlock secrets of lung blood pressure in heart failure
- New MRI study reveals how balloon procedure helps lungs and heart
- New combo therapy aims to ease strain on heart in rare lung condition