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Massive hunt for Huntington's clues: 2,500 volunteers needed for spinal fluid study

NCT ID NCT02855476

Knowledge-focused Sponsor: University College, London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to collect cerebrospinal fluid and blood samples from 2,500 people at various stages of Huntington's disease, as well as healthy volunteers. The goal is to find biological markers that can help researchers develop new treatments. Participants must be between 11 and 75 years old and, except for family or community controls, have had a genetic test for Huntington's.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could identify key biological markers that help develop new treatments for Huntington's disease.
What could go wrong
This is an observational study, not a treatment trial. It may not directly lead to a therapy, and results depend on participant diversity and sample quality.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants across 8 clinical cohorts will be enrolled at multiple sites up to an estimated minimum of 2500 participants or until the study is terminated by either the Funding Source or Sponsor

Ages

11 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age (18-75 years controls, early/late premanifest HD and incomplete penetrance HD, 21-75 years early/moderate/advanced manifest HD, ≥11 years juvenile HD) * Enroll HD participant * Capable of consenting or have a legal representative (parent/guardian for juveniles) * Capable of complying with study procedures * All participants other than family and community controls must have had a genetic test for HD Exclusion Criteria: * Drug trial within 30 days of any sampling visit * Changes in medication (antidepressant, psychoactive, psychotropic or other medications or nutraceuticals used to treat HD within 30 days) * Antiplatelet or anticoagulant therapy within 14 days * Significant comorbidity * Needle phobia, headache, spinal surgery / deformity * Clotting or bruising disorder * Screening blood test abnormalities \>10% outside normal range * Drug / alcohol abuse * Positive urine pregnancy test at any screening or sampling visit for females of childbearing potential * Predictable non compliance or unwillingness * Serious adverse event related to HDClarity study procedures or any lumbar puncture procedure performed for any reason in the previous 30 days

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Conditions

The condition(s) this trial relates to.

Huntington disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Huntington's disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    32 sites in 9 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Birmingham Huntingtons Disease Clinic

    RECRUITING

    Birmingham, West Midlands, B15 2 FG, United Kingdom

  • Cambridge University Hospitals NHS Foundation Trust

    RECRUITING

    Cambridge, CB2 0PY, United Kingdom

  • Cardiff University

    RECRUITING

    Cardiff, CF24 4HQ, United Kingdom

  • Cenexel

    RECRUITING

    Englewood, Colorado, United States

  • Centre Hospitalier Universitaire d'Angers

    RECRUITING

    Angers, 49000, France

  • Centre for Movement Disorders

    COMPLETED

    Toronto, Ontario, M3B 2S7, Canada

  • Cruces University Hospital

    ACTIVE_NOT_RECRUITING

    Bilbao, Biscay, 48903, Spain

  • Dresden University

    RECRUITING

    Dresden, Saxony, 01307, Germany

  • Fife Health Board - Whyteman's Brae Hospital

    ACTIVE_NOT_RECRUITING

    Kirkcaldy, KY1 2ND, United Kingdom

  • Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

    ACTIVE_NOT_RECRUITING

    Milan, 20133, Italy

  • George Huntington Institute

    RECRUITING

    Münster, 48149, Germany

  • Georgetown University

    RECRUITING

    Washington D.C., District of Columbia, 20057, United States

  • Glasgow Clinical Research Facility

    RECRUITING

    Glasgow, Scotland, G51 4TF, United Kingdom

  • Gulbenkian Institute of Molecular Medicine

    RECRUITING

    Lisbon, 1649-028, Portugal

  • Hospital de Sant Pau

    RECRUITING

    Barcelona, 08041, Spain

  • Institute of Psychiatry and Neurology

    ACTIVE_NOT_RECRUITING

    Warsaw, 02-957, Poland

  • John Hopkins University

    RECRUITING

    Baltimore, Maryland, 21287, United States

  • Kbo-Isar-Amper-Klinikum Taufkirchen (Vils)

    RECRUITING

    Taufkirchen, 84416, Germany

  • Le Centre Hospitalier Universitaire de Bordeaux

    RECRUITING

    Bordeaux, 33076, France

  • Leeds Teaching Hospital Trust

    RECRUITING

    Leeds, LS7 4SA, United Kingdom

  • Lega Italiana Ricera Huntington

    RECRUITING

    Rome, 00185, Italy

  • NZ Brain Research Institute

    RECRUITING

    Christchurch, Canterbury, 8011, New Zealand

  • North Bristol NHS Trust

    ACTIVE_NOT_RECRUITING

    Bristol, BS10 5NB, United Kingdom

  • North York General Hospital

    RECRUITING

    Toronto, Ontario, M2K 1E1, Canada

  • Oxford University Hospitals NHS Foundation Trust

    RECRUITING

    Oxford, OX3 9DU, United Kingdom

  • Ramón y Cajal Universitary Hospital

    RECRUITING

    Madrid, 28034, Spain

  • Royal Devon & Exeter NHS Foundation Trust

    RECRUITING

    Exeter, Devon, EX2 5DW, United Kingdom

  • St George's University Of London

    RECRUITING

    London, SW17 0RE, United Kingdom

  • St Josef And Elisabeth Hospital

    RECRUITING

    Bochum, 44791, Germany

  • The Ottawa Hospital

    RECRUITING

    Ottawa, Ontario, K1Y 4E9, Canada

  • The University of Auckland

    RECRUITING

    Grafton, Auckland, 1023, New Zealand

  • The Walton Centre NHS Foundation Trust

    RECRUITING

    Liverpool, L9 7LJ, United Kingdom

  • University College London Hospitals NHS Foundation Trust

    RECRUITING

    London, NW1 2PG, United Kingdom

  • University Hospital Ulm

    RECRUITING

    Ulm, Baden-Wurttemberg, 89081, Germany

  • University Hospital of Erlangen

    RECRUITING

    Erlangen, 91054, Germany

  • University Hospitals Plymouth NHS Trust

    RECRUITING

    Plymouth, PL6 5FP, United Kingdom

  • University of British Columbia, The Centre for Huntingtons Disease

    ACTIVE_NOT_RECRUITING

    Vancouver, British Columbia, V6T 2B5, Canada

  • University of Texas Health Science Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37212, United States

  • Wake Forest University

    COMPLETED

    Winston-Salem, North Carolina, 27109, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.