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Gut bacteria diet may boost weight loss after surgery

NCT ID NCT07268508

Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a special diet that promotes a diverse gut microbiome can help people lose more weight and keep it off after bariatric surgery. Sixty adults aged 25-65 who are scheduled for weight-loss surgery will be randomly assigned to receive either standard nutritional advice or advice focused on increasing gut bacteria diversity. Researchers will track changes in gut bacteria, eating habits, taste, and overall health for one year after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Apr 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Between 25 and 65 years old * Undergoing either sleeve gastrectomy or Roux-en-Y gastric bypass * With grade 3 obesity (BMI≥40 kg/m²) or with BMI≥35 kg/m² and at least one comorbidity likely to be improved after surgery, with the exception of type 2 diabetes * Signed consent form * Living less than an hour and 30 minutes from the hospital * Presence of effective and stable contraception for women of childbearing potential Exclusion Criteria: * Type 2 diabetes * Presence of a contraindication to bariatric surgery * Presence of gastrointestinal pathologies with an inflammatory component, known gastroparesis, total gastrectomy, colectomy, exocrine pancreatic insufficiency, known endocrine pathologies inducing hyperglycaemia (uncontrolled dysthyroidism, acromegaly, hypercorticism, etc.), severe chronic renal insufficiency (\< 30mL/min), or hepatocellular insufficiency * Claustrophobic * Pregnant or breastfeeding women * Taking an obesity treatment 3 months before surgery * Taking a corticoids, immunosuppression, anabolizing, or growing hormones, antibody treatments less than 3 months before inclusion * Daily taking of laxatives or drugs that can strongly interfere with the composition of the intestinal microbiota. If taken sporadically, the patient can be included at a distance (3 weeks) from the laxatives taken. * Specific diets (vegetarian, vegan or without gluten) * No French speaker * Already included in other study * Donated blood in the last two months * Without freezer access * With allergy or intolerance to food propose in ad libitum buffet

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Conditions

The condition(s) this trial relates to.

Food Preferences Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bariatric surgery Obesity (disorder)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centre de recherche en nutrition humaine de Rhône-Alpes

    NOT_YET_RECRUITING

    Pierre-Bénite, 69310, France

  • Hospital Edouard Herriot, digestive surgery department

    RECRUITING

    Lyon, 69310, France

  • Hôpital Lyon sud, Endocrinology Diabetes Nutrition department

    NOT_YET_RECRUITING

    Pierre-Bénite, 69310, France

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