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Animal membranes battle to save molars: which works best?

NCT ID NCT06681532

Disease control Sponsor: Ibrahim Ahmed Zein Elabdin Ahmed Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two different membranes (one from cow pericardium, one from cow collagen) used with a bone graft to treat a specific type of bone loss between the roots of lower molars. Twenty patients with class II furcation defects will receive one of the two treatments, and their gum health and bone levels will be measured at 3 and 6 months. The goal is to see which membrane leads to better bone and gum attachment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bovine bone graft mixed with concentrated growth factor, covered with either native collagen membrane or bovine pericardium membrane
What this could lead to
If successful, this could point toward a better way to repair bone loss around the roots of lower molars, potentially saving teeth that might otherwise be lost.
What could go wrong
This is a very small, early-stage trial with only 20 patients, so results may not apply to everyone. The membranes are from animal tissue, which could cause allergic reactions or rejection in some people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Sep 2024

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Display a buccal or lingual class II furcation defect (Hamp et al. classification) in their lower molars. * The tooth with a horizontal clinical attachment level (HCAL) greater than 3mm and a probing depth (PD) greater than or equal to 6mm in the mid-buccal or mid-lingual sites. * Have not undergone any periodontal treatment in the past 6 months. * A plaque index score (PI) below 1 at surgery, assessed using the Ramfjord teeth. Exclusion Criteria: * Patients with class I or class III furcation defects. * Systemic disease contraindicating periodontal surgery. * Taking any medication that may have an impact on their periodontal health within the last 6 months. * Smoking. * Being pregnant or lactating. * Teeth with periapical lesions and teeth with mobility. * Third molars or teeth with improper endodontic or restorative treatment. * Patients with furcation caries, metal crowns in the furcation area or amalgam fillings near the alveolar crest.

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Conditions

The condition(s) this trial relates to.

Furcation Defects

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Furcation defects

Contacts and locations

Locations

  • Faculty of dentistry , Mansoura university

    Al Mansurah, Dakahlia Governorate, 35516, Egypt

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Other studies related to the condition(s) this trial covers.