Grape powder may help aging immune systems — a trial puts it to the test
NCT ID NCT07079982
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This study tests whether daily consumption of freeze-dried grape powder can improve immune function and reduce inflammation in healthy adults aged 50 to 75. Participants will drink a grape powder beverage or a placebo for four weeks each, while avoiding grapes and other polyphenol-rich foods. Researchers will measure immune markers and inflammatory responses from blood samples to see if grapes can positively influence age-related changes in immunity.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Freeze-dried whole grape powder
- What this could lead to
- If it works, this could point toward a simple dietary addition that supports immune health and reduces inflammation in older adults.
- What could go wrong
- This is a small, early-stage study, and the effects may be modest or not translate to real-world benefits. Participants must avoid grapes and other polyphenol-rich foods, which may be challenging.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 28 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2025
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 50-75 years old (at time of screening) * Body mass index (BMI) 18.5 to \< 30 kg/m2 * Willing to consume grape and control powder during study periods, and refrain from eating grapes and certain other polyphenol-rich foods and beverages during the study * Do not fit any exclusion criteria Exclusion Criteria: * \<50 years old and \>75 years old * BMI \<18.5 and ≥ 30 kg/m2 or body weight \< 110 pounds * Experienced \>10% weight change in the past 4 weeks * Elevated fasting glucose levels (fasting glucose higher than 126 mg/dL) and triglycerides greater than 500 mg/dL * Self-reported and/or physician-diagnosed history of diabetes mellitus, coronary heart disease, stroke, renal or liver disease, cancer, eating disorders, certain severe and/or relapsing/remitting autoimmune, inflammatory, or metabolic diseases, chronic infections, scleroderma, blood clotting disorders, intravenous drug use, or current pregnancy or lactation * Allergy to grapes or any ingredients in the grape or control powders * Implanted medical device (e.g., pacemaker) or other health condition that would prevent measurement of body composition by bioelectrical impedance * Currently taking lipid-lowering medications (e.g., statins, fibrates), glucose-regulating medications, anti-inflammatory medications (e.g., non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids), or medications that primarily affect blood clotting (e.g., warfarin), long-term antibiotics in the last 3 months, active use of probiotics during the intervention * Active smoker
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Department of Nutritional Sciences
RECRUITINGStorrs, Connecticut, 06269, United States
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