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Grape extract and exercise: a natural combo for blood pressure?

NCT ID NCT06985407

Disease control Sponsor: University of Castilla-La Mancha Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether taking grape extract, a supplement rich in polyphenols, could improve blood pressure and blood vessel function after exercise in people with slightly high blood pressure (prehypertension). Ten sedentary adults took either grape extract or a placebo for a week, then switched after a break. Researchers measured blood pressure and artery function right after exercise and over 24 hours. The goal was to see if the combination works better than exercise alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
grape extract (VinteraTM Premium OPC)
What this could lead to
If it works, this could point toward a natural supplement to help control blood pressure when paired with exercise.
What could go wrong
This is a very small, early study with only 10 people, so results may not apply to everyone. The effects might be small or not last long.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

10 people

The number who actually took part.

Started

Feb 2026

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Sedentary individuals (\<120 min·wk-1 of moderate-intensity activity assessed by 7-d IPAQ). * Aged 25-70 years and BMI 18-40 kg/m2. * Elevated BP (i.e., prehypertensive; systolic and diastolic BP between 120-139 and/or 80-89 mmHg, respectively) Exclusion Criteria: * Weight instability (\>5kg change in body mass over last 6 months) * Pregnant or lactating * Changes in physical activity over the last 3 months and planning on physical activity, or diet throughout the intervention. * Untreated cardiovascular or renal disease, peripheral vascular disease, hypertension, and any disease associated with exercise intolerance. * Currently taking dietary supplements that influence the cardiovascular response (e.g., polyphenols, omega-3 fatty acids, Magnesium, nitrates, L-arginine, red ginseng, natto, ginkgo, CoQ10) or used in the last month. * Current or recent use (within the past 6 months) of tobacco or nicotine-containing products, or illicit drugs. * Any medical condition or medication that could introduce bias into the study (e.g. neurological disorders)

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Conditions

The condition(s) this trial relates to.

Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Blood pressure monitoring, ambulatory Exercise response Polyphenol

Contacts and locations

Locations

  • UCLM

    Toledo, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.