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The genetic clues behind underbites: a new study digs deep

NCT ID NCT07749638

Knowledge-focused Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study looks at whether certain genetic variations are linked to a type of underbite called skeletal Class III malocclusion. Researchers will collect saliva samples, facial photos, and X-rays from people with and without the condition to compare their DNA. The goal is to identify genetic markers that could help detect this bite problem earlier and understand its causes better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If specific genetic markers are linked to underbite, it could enable earlier detection and more personalized orthodontic treatment planning.
What could go wrong
This is an observational study, so it won't directly test a treatment. The findings may not apply beyond the Egyptian population studied, and genetic links may not translate into practical screening tools.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

93 people

The number who actually took part.

Started

Oct 2023

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

* Patients of Egyptian nationality. * ANB (angle between point A, nasion and point B at nasion) angle (point A-nasion point B) of less than 0 degrees. * Negative Wits appraisal greater than -3.0 mm.

Ages

10 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for Control group: * Patients of Egyptian nationality. * ANB from 0° to 4.8°.ANB from 0° to 4.8°. * Wits appraisal no less than -3.0 mm. Inclusion Criteria for Study group: * Patients of Egyptian nationality. * ANB (angle between point A, nasion and point B at nasion) angle (point A-nasion point B) of less than 0 degrees. * Negative Wits appraisal greater than -3.0 mm. Exclusion Criteria: * The presence of any growth disturbances, syndromes, congenital abnormalities, \& endocrine disorders. * Patients subjected to previous orthodontic, orthopedic, or orthognathic treatment. * Poor quality of radiographic records. * Consent form not signed. * Trauma.

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Conditions

The condition(s) this trial relates to.

autosomal dominant prognathism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Skeletal class III malocclusion

Contacts and locations

Locations

  • Faculty of Dentistry, Cairo University

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.