The genetic clues behind underbites: a new study digs deep

NCT ID NCT07749638

Completed Knowledge-focused Sponsor: Cairo University Source: ClinicalTrials.gov ↗

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study looks at whether certain genetic variations are linked to a type of underbite called skeletal Class III malocclusion. Researchers will collect saliva samples, facial photos, and X-rays from people with and without the condition to compare their DNA. The goal is to identify genetic markers that could help detect this bite problem earlier and understand its causes better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If specific genetic markers are linked to underbite, it could enable earlier detection and more personalized orthodontic treatment planning.
What could go wrong: This is an observational study, so it won't directly test a treatment. The findings may not apply beyond the Egyptian population studied, and genetic links may not translate into practical screening tools.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autosomal dominant prognathism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SKELETAL CLASS III MALOCCLUSION

Contacts and locations

Locations

Faculty of Dentistry, Cairo University

Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.