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Clear aligner aims to guide jaw growth and fix underbite without metal braces

NCT ID NCT07703007

Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This trial tests a custom clear aligner designed to correct skeletal Class III malocclusion (underbite) in children aged 8-11 who are still growing. The aligner uses small bite blocks with angled surfaces to gently guide the lower jaw forward during everyday use. Researchers will measure changes in jaw position, tooth alignment, and facial appearance using X-rays taken before and after treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a customized functional clear aligner appliance designed as a reverse twin block with 70° inclined planes
What this could lead to
If successful, this approach could offer a more comfortable and aesthetic alternative to traditional braces for correcting underbite in growing children.
What could go wrong
This is a small, early-stage study with only 15 participants, so results may not apply to all cases. The device may not achieve the desired skeletal changes or could cause discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

8 to 11 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients' age (8-11) years (CVM stages 2-3) * Mild class III skeletal pattern (Wits appraisal = 0 to -8) * Mild to moderate reverse overjet (-1 to -4) * Overbite (1-5) * Growing patients * Average or below average maxillary-mandibular plane angle and lower facial height * Mild incisors compensations Exclusion Criteria: * Severe class III skeletal pattern * Long facial height * Bad oral hygiene * Systemic condition that may interfere with treatment

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Conditions

The condition(s) this trial relates to.

autosomal dominant prognathism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Skeletal class III malocclusion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Dentistry, Mansoura University

    Al Mansurah, Dakahlia Governorate, Egypt

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