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Can a tweaked jaw surgery cut nerve damage risk?

NCT ID NCT07746700

Disease control Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial tests a modified jaw surgery technique, called low sagittal medial ramus osteotomy, for people with severe bite misalignment (skeletal Class II or III malocclusion). The procedure aims to reposition the jaw with fewer complications than the standard surgery, particularly by reducing the chance of nerve injury and unwanted bone fractures. Researchers will evaluate outcomes in 11 healthy adults aged 18 to 45, measuring both surgical success and nerve function recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Low sagittal medial ramus osteotomy, a modified surgical procedure for jaw repositioning
What this could lead to
If successful, this modified jaw surgery could offer a safer way to correct severe bite misalignment, with fewer nerve injuries and fewer surgical complications.
What could go wrong
This is a small, early-stage trial with only 11 participants, so results may not apply broadly. Surgery carries inherent risks like infection, bleeding, or nerve damage, and the modified technique may not prove safer than the standard approach.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 11 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with skeletal Class II or Class III malocclusion requiring mandibular orthognathic surgery. * Age range from 18 to 45 years old. * Systematically healthy patients classified as ASA physical status I or II (American Society of Anesthesiologists) Exclusion Criteria: * Patients with a pre-existing history of inferior alveolar nerve (IAN) sensory impairment. * Patients with active or severe degenerative joint disease (DJD). * Patients with a prior history of orthognathic surgical procedures. * Patients presenting with systemic diseases or conditions known to compromise normal bone healing.

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Conditions

The condition(s) this trial relates to.

autosomal dominant prognathism Dentofacial Deformities

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dentofacial deformities Skeletal class II malocclusion Skeletal class III malocclusion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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