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Colonoscopy sedation study: which drug is safer for Seniors' brains?

NCT ID NCT07384169

Knowledge-focused Sponsor: Ankara City Hospital Bilkent Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at 164 adults aged 65 and older who had a colonoscopy with sedation. Researchers compared two common sedatives—propofol and dexmedetomidine—to see how they affected thinking and memory. They also checked whether frailty played a role. Participants took a simple thinking test before the procedure and again 2 and 24 hours after. The goal was to find out which sedation method might be safer for older patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
propofol and dexmedetomidine
What this could lead to
If it works, this could help doctors choose the safest sedation method for older adults undergoing colonoscopy to protect their thinking skills.
What could go wrong
This is a small, completed observational study, not a large trial. Results may not apply to all older adults or other procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

164 people

The number who actually took part.

Started

Aug 2023

Finished

Jan 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

65 years and older

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥65 years * Elective colonoscopy * ASA physical status I-III * Provision of written informed consent Exclusion Criteria: * Second- or third-degree atrioventricular (AV) block * A recent history of strokes * Severe hypotension * Cardiorespiratory instability * Substance abuse * Psychotic illness * Severe dementia

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Conditions

The condition(s) this trial relates to.

cognitive disorder Frailty

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognition Colonoscopy Frailty Geriatric anesthesia Sedation

Contacts and locations

Locations

  • Ankara Bilkent City Hospital

    Ankara, Çankaya, 06800, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.