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Simple breath holds may help doctors avoid fluid overload after heart surgery

NCT ID NCT05957003

Knowledge-focused Sponsor: Tanta University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two simple breathing maneuvers—briefly pausing the ventilator at different points—to see if they could predict whether a patient needs more fluids after heart surgery. 90 adults on ventilators after cardiac surgery were included. The goal was to find a reliable, non-invasive way to guide fluid treatment and prevent complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, these simple bedside tests could help doctors give the right amount of fluids to patients after heart surgery, avoiding fluid overload.
What could go wrong
This is a small, completed study focused on prediction accuracy, not a treatment. Results may not apply to all heart surgery patients or those with irregular heart function.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

Aug 2023

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients on mechanical ventilation * Patients ≥18 years of age * patients undergoing cardiac surgery (coronary artery bypass graft, valve repair/ replacement, combined cardiac surgery) * patients with normal systolic function of the left and right ventricle * patient is mechanically ventilated with a protective lung strategy Exclusion Criteria: * Patients with Spontaneously breathing activity * Patients undergoing emergent cardiac surgery. * Patient with severe peripheral arterial occlusive disease * Pregnant women * Contraindication of passive leg raising test * unstable post-operative course * Post-operative complications such as uncontrolled bleeding, severe neurologic impairment, or accidental mechanical complications; * presence of residual severe tricuspid or any valvular regurgitations * low cardiac output, low ejection fractions (EF ≤45%) * open chest,Pao2/Fio2 ≤ 200

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Conditions

The condition(s) this trial relates to.

Edema Postoperative Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac surgery Fluid overload Postoperative complications

Contacts and locations

Locations

  • Faculty of medicine, Tanta university

    Tanta, El Gharbyia, 31111, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.