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Which tooth sealant holds up best on fragile molars? a Head-to-Head test

NCT ID NCT07732790

Disease control Sponsor: National Research Centre, Egypt Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests two types of fissure sealants—a standard resin-based one and a newer giomer-based one—on first permanent molars affected by molar incisor hypomineralization (MIH), a condition that leaves enamel weak and prone to decay. Researchers will apply the sealants to children aged 6 to 12 and check them over time for retention, decay, and other signs of failure. The goal is to see which sealant protects these vulnerable teeth better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fissure sealants (resin-based and giomer-based)
What this could lead to
If one sealant type proves more durable, it could offer a better way to protect vulnerable molars in children with MIH, reducing future decay.
What could go wrong
This is a small, early-stage trial with only 22 children, so results may not apply broadly. Both sealants may perform similarly, or one may fail more often.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

22 people

The number who actually took part.

Started

Jun 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 12 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Apparently Healthy Children aged 6-12 years having at least one fully erupted First Permanent Molar (FPM) with MIH indicated for non-invasive fissure sealant. * Cooperative children. * Occlusal mild MIH defects (demarcated white, yellow or brown lesions) * sound surfaces and no incipient enamel caries, where moist control can be achieved. Exclusion Criteria: * Children having hypomineralized FPMs with post eruption breakdown (PEB). * Cavitated carious lesions. * Restorations, fixed orthodontic appliances. * Enamel defect(s) due to a condition other than MIH.

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Conditions

The condition(s) this trial relates to.

Molar Hypomineralization

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fissure sealant Molar hypomineralization, incisor Resin based sealers

Contacts and locations

Locations

  • National Research Centre

    Cairo, Giza Governorate, 12572, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.