Liver transplant patients may cut lifelong drugs with simple ultrasound test
NCT ID NCT07206277
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a special ultrasound called a fibroscan can help doctors safely lower the dose of anti-rejection drugs in liver transplant recipients. Participants must be at least 2 years post-transplant, have normal liver blood tests, and not have autoimmune liver disease or recent rejection. The goal is to reduce drug doses by 30% without causing rejection, which could lower side effects like kidney problems, diabetes, and cancer.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2025
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 2 years or more post-liver transplant * 18 years or older Exclusion Criteria: * diagnosis of either acute or chronic rejection in the past 12 months * abnormal liver enzymes (ALT \> 50; bilirubin \> 19 umol/L) * transplant for autoimmune liver disease (autoimmune hepatitis, primary sclerosing cholangitis, and primary biliary cholangitis) * presence of HCV RNA * presence of HBV DNA * presence of class II donor specific antibodies (DSA; pre-existing or de novo) * beyond 6 years of transplantation * presence of ascites, decompensated heart failure, biliary obstruction, CKD (bl eGFR 30 ml/min/1.73m2 or less), re-transplantation, or multi-visceral transplant.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Alberta
RECRUITINGEdmonton, Alberta, T6G2R3, Canada
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