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Which sedative works best for ventilator patients? new trial aims to find out

NCT ID NCT06479655

Symptom relief Sponsor: Universiti Sains Malaysia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares fentanyl and morphine, two painkillers used to sedate adults on breathing machines in the ICU. Researchers want to see which drug helps patients reach the right sedation level faster and with fewer extra doses. The trial will enroll 116 patients and also look at how long they need the breathing machine and their ICU stay.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fentanyl and morphine
What this could lead to
If this trial shows one drug works better, it could help ICU patients get the right sedation faster, possibly reducing time on a ventilator.
What could go wrong
This is a small, single-center study (116 people) comparing two well-known drugs, so it won't lead to a new treatment. Results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 116 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2024

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \>18 years old * Patients who are expected by the ICU team to require invasive mechanical ventilation in ICU for at least more than 24 hours and for whom the ICU team decides to initiate continuous infusion of sedation * A patient who was ventilated and sedated not more than 12 hours before ICU admission. Exclusion Criteria: * Patients with chronic use of narcotics * Patients with chronic liver failure or end-stage renal failure * Patients with severe chronic neurocognitive dysfunction * Patients with drug overdose * Patients with a known allergy to either morphine or fentanyl * Patients who are receiving neuromuscular blockers * Patients who are pregnant * Patients who are diagnosed to have severe traumatic brain in

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Effect of drug

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital Universiti Sains Malaysia

    RECRUITING

    Kota Bharu, Kelantan, 16150, Malaysia

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