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Small study pinpoints ideal sedation dose for colonoscopy

NCT ID NCT07166640

Knowledge-focused Sponsor: Kocaeli City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study aimed to find the right dose of propofol needed to insert a colonoscope comfortably in 27 adults aged 18-65. Researchers adjusted the dose up or down based on each patient's response, using a standard method. The goal was to determine the dose that works for half of patients, helping guide sedation during colonoscopies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
propofol
What this could lead to
If successful, this could help doctors use the right amount of propofol for colonoscopies, making the procedure more comfortable and safer for patients.
What could go wrong
This is a very small, early study with only 27 people, so the results may not apply to everyone. It only looks at dosing for one specific moment in the procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

27 people

The number who actually took part.

Started

Sep 2025

Finished

Oct 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients who provided informed consent to participate * Patients scheduled for colonoscopy * ASA physical status I-III * Male and female patients aged 18-65 years Exclusion Criteria: * Patients who did not provide consent * Known allergy to propofol * Body weight \<40 kg * Body mass index (BMI) \>30 kg/m² * Presence of acute or chronic pain * Chronic alcohol consumption * Use of antipsychotic, antidepressant, or hypnotic medications * Patients with obstructive sleep apnea syndrome (STOP-Bang score ≥3) * Patients with known anorectal diseases such as hemorrhoids, anal fissure, or anal fistula * History of oncological disease * Uncontrolled hypertension (blood pressure \>180/110 mmHg) * Severe hepatic or renal dysfunction * Acute respiratory tract infection or other chronic respiratory disorders * Patients with a history of colorectal surgery

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Effect of drug

Contacts and locations

Locations

  • University of Health Sciences Kocaeli City Hospital

    Kocaeli, Izmit, 41100, Turkey (Türkiye)

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