Could a simple breath stop fever seizures? new study investigates
NCT ID NCT01906619
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 100 children with fever to see if those who have febrile seizures breathe differently. Researchers measured breathing rate, carbon dioxide levels, and body temperature while children slept. The goal is to understand why some children have seizures during fever, which could lead to new ways to stop them.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could provide the basic data needed to design a future trial testing carbon dioxide inhalation to stop febrile seizures.
- What could go wrong
- This is an observational study with only 100 children, so results may not apply to all. It does not test any treatment, so direct benefits are not expected.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Start date
-
Jul 2011
- Finished
-
Dec 2014
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Children with febrile illness between 3 months and 5 years of age with a body temperature of \>38.0 during the monitoring period.
- Ages
-
3 months to 5 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Febrile illness with body temperature ≥38.0 degree C * 50% of study population: never had a febrile seizure * 50% of study population: simple or complex febrile seizure within one day of investigation * Change of body temperature of ≥1.0 degree C during the monitoring period * Provision of written informed consent by the parents or guardians of the child * Artefact-free simultaneous measurement of respiratory rate, pCO2 (transcutaneous probe), body temperature (rectal probe), and heart rate during change of body temperature of ≥1.0 degree C. Exclusion Criteria: * Past history of afebrile seizures * Past history of neonatal seizures * Retarded psychomotor development * Chronic respiratory disease * Cardiologic disease * Severe other organ disease * Permanent medication for chronic disorder * Therapeutic increase of inspiratory oxygen concentrations during the observational period
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Febrile illness acute are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Charité Universitätsmedizin Berlin
Berlin, 13353, Germany
More trials for these conditions
Other studies related to the condition(s) this trial covers.