Cancer survivors may carry hidden aging markers that raise disease risk
NCT ID NCT07114614
First seen Jun 27, 2026 · Last updated Aug 27, 2026 · Updated 4 times
Summary
This study will compare levels of fatty acid binding proteins and cellular aging markers in 120 cancer survivors versus people who never had cancer. Researchers want to see if these markers are higher in survivors and linked to conditions like diabetes and high blood pressure. Participants will provide blood samples, and no treatment is given.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help identify biomarkers that predict chronic disease risk in cancer survivors, potentially guiding future preventive care.
- What could go wrong
- This is an observational study with no treatment being tested. It is early-stage research, and findings may not lead to direct clinical changes or apply to all survivors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
For pediatric control participants, labs will be drawn with IV placement prior to procedure or sedation. Measurements will be taken during the same visit. If desired by patient and parent, a separate research visit can be arranged for participants to have labs drawn at their convenience. For adult control participants, a research visit will be arranged at the participants' convenience for measurements to be obtained and study labs to be drawn.
- Ages
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5 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosis of at least one malignancy for which chemotherapy, radiation, and/or stem cell transplantation was utilized as part of treatment * Completed all therapeutic interventions for their malignancy and are at least 2 years off therapy * At least 1-year post-stem cell transplant for malignant condition Exclusion Criteria: 1. Pregnancy at the time of the study 2. Any autoimmune condition including but not limited to lupus, rheumatoid arthritis, Crohn's disease, ulcerative colitis, type 1 diabetes, EXCEPT well-controlled autoimmune hypothyroidism for at least 6 months 3. Presence of active graft versus host disease 4. Malignancy treated using surgery only 5. Acute relapsed disease or second malignancy 6. Transplant for non-malignant conditions (e.g. cell disease, Hurler syndrome) 7. Currently taking systemic steroids and/or immunosuppressant medications 8. Acute illness necessitating hospitalization in the 30 days prior to blood draw 9. Presence of a chronic inflammatory disease EXCEPT obesity 10. Fever, active infection or inflammation, or taking antibiotics at the time of blood draw 11. A diagnosis of Type 2 diabetes or Hypertension treated with medication 12. Currently lipid lowering medications 13. Growth hormone deficiency or hypothalamic dysfunction
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Case Comprehensive Cancer Center, UH Rainbow Babies & Children's Hospital
RECRUITINGCleveland, Ohio, 44106, United States
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