Bacteria wall chemical injected into tumors: could it wake up the immune system?
NCT ID NCT05751837
First seen Jun 20, 2026 · Last updated Jun 20, 2026
Summary
This early study tested whether a sterile chemical from bacteria walls, called LPS, can be safely injected into abdominal tumors during keyhole surgery. Twelve adults with advanced digestive tract tumors received one injection into a tumor, and researchers checked for side effects and immune changes. The goal was to see if this approach is safe enough to study further as a potential immunotherapy.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Allegheny Health Network Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
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Allegheny Health Network West Penn Hospital
Pittsburgh, Pennsylvania, 15224, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Lipopolysaccharide (LPS), a chemical from bacteria
What this could lead to
If it works, this could point toward a new way to stimulate the immune system to fight abdominal tumors from the inside.
What could go wrong
This is a very early Phase 1 trial with only 12 people, focused on safety. It may not show any anti-tumor effect, and side effects from the injection are unknown.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.