MALIGNANCY

This trial tests atezolizumab, a drug already approved for several cancers, in people with rare cancers that have high tumor mutational burden (TMB) or microsatellite instability (MSI). The goal is to see if the drug can shrink tumors or stop them from growing for at least 24 wee…

This trial tests capmatinib, a drug already approved for certain lung cancers, in adults with rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if it can shrink tumors or stop them from growing for at least 24 weeks. The goal is …

This trial is testing a drug called entrectinib (Rozlytrek) in people with rare cancers that have a specific genetic change called a ROS1 gene fusion. The drug is already approved for some lung cancers, and researchers want to see if it can help shrink or control other tumor type…

This study compares two ways to rebuild the chest wall after removing a tumor: using twisted steel wires versus bone cement. The goal is to see which method causes less pain, helps breathing better, and has fewer complications. About 50 adults needing chest wall reconstruction wi…

This study is testing a new type of PET scan that uses special probes to highlight digestive system cancers, such as stomach, liver, colon, and pancreatic cancers. Researchers will enroll 400 adults to see how well this imaging method finds tumors and tracks their response to tre…

This study tests a special radiation technique called Spatially Fractionated Radiation (SFR) for people with large tumors (over 8 cm) or tumors that resist standard radiation. Instead of multiple hospital visits, SFR delivers a single treatment through a grid-like device. The goa…

This study compares two types of sedation used during a procedure to drain blocked bile ducts. About 98 adults will receive either propofol-remifentanil or propofol-ketamine. The goal is to see which method leads to faster recovery, better comfort, and fewer side effects, especia…

This study offers girls facing medical treatments that could harm their fertility the chance to freeze ovarian tissue for future use. Researchers will track how many girls choose this option and, later, how many use the tissue to try to have children. The goal is to understand tr…

This study looks at whether repeated sessions of hyperbaric oxygen therapy (HBOT) can damage DNA in people who have had radiation for cancer. HBOT is used to help heal tissues damaged by radiation, but it also creates reactive oxygen molecules that might harm DNA. Researchers wil…

This study collects blood, tissue, and medical information from 240 cancer patients who have had serious side effects from immunotherapy. The goal is to store these samples in a national biorepository for future research. By studying these samples, scientists hope to better predi…