MALIGNANCY

This study tests a drug called entrectinib, already approved for some lung and solid tumors, in people with rare cancers that have a specific genetic change (ROS1 fusion). About 30 adults and children with various cancer types will receive the drug to see if it shrinks tumors or …

This study tests capmatinib, a drug already approved for certain lung cancers, in adults with rare cancers that have specific MET gene changes. About 30 people will take part to see if the drug can shrink tumors or stop cancer from growing for at least 24 weeks. The goal is to fi…

This study tests atezolizumab, a drug already approved for some cancers, in people with rare cancers that have high tumor mutational burden (TMB) or microsatellite instability (MSI). About 30 adults and children with these genetic changes will receive the drug to see if their tum…

This study compares two ways to rebuild the chest wall after removing a tumor: using twisted steel wires versus bone cement. The goal is to see which method causes less pain, helps breathing better, and has fewer complications. About 50 adults needing chest wall reconstruction wi…

This study is testing a new type of PET scan that uses special probes to highlight digestive system cancers, such as stomach, liver, colon, and pancreatic cancers. Researchers will enroll 400 adults to see how well this imaging method finds tumors and tracks their response to tre…

This study compares two types of sedation used during a procedure to drain blocked bile ducts. About 98 adults will be randomly assigned to receive either propofol-remifentanil or propofol-ketamine. The goal is to see which method leads to faster recovery, better comfort, and few…

This study looks at whether repeated sessions of hyperbaric oxygen therapy (HBOT) can damage DNA in people who have had radiation for cancer. HBOT is used to help heal tissues damaged by radiation, but it also creates reactive oxygen molecules that might harm DNA. Researchers wil…

This study collects blood, tissue, and medical information from 240 cancer patients who have had serious side effects from immunotherapy. The goal is to store these samples in a national biorepository for future research. By studying these samples, scientists hope to better predi…