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Needle or no needle? study pits microneedling against facial exercises for wrinkle reduction

NCT ID NCT07285577

Symptom relief Sponsor: Kasr El Aini Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two approaches for facial rejuvenation in 40 women with mild to moderate aging. One group received three sessions of fractional microneedling radiofrequency, a device that uses tiny needles and heat to tighten skin. The other group did an 8-week facial muscle exercise program with daily practice. Researchers measured wrinkle severity, aging scores, and satisfaction to see which method worked better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Fractional microneedling radiofrequency (device) and facial muscle exercises (behavioral)
What this could lead to
If successful, this could show that either treatment effectively reduces signs of facial aging, offering a non-surgical option for rejuvenation.
What could go wrong
This is a small, completed trial with only 40 participants, so results may not apply to everyone. The treatments are cosmetic and may not produce dramatic or lasting changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Apr 2023

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female participants aged ≥30 years * Mild to moderate facial aging (defined as grade 2-3 on Modified Quantitative Comprehensive Grading Scale of Aging and grade 2-4 on Wrinkle Severity Rating Scale) * Literate and able to follow instructions * Familiar with using online applications (e.g., Zoom) and have reliable internet access * Provided written informed consent for participation and photography Exclusion Criteria: * Age \<30 years * Severe facial aging (grade 4 on MQCGS and grade 5 on WSRS) * Current smoker * History of previous facelift surgery or thread lifting Botulinum toxin or filler injection within the past 12 months * Mesotherapy or topical rejuvenating therapy within the past 3 months * Body dysmorphic disorder * Medical history of autoimmune diseases, diabetes, or systemic conditions affecting healing * Pregnancy or lactation * Illiteracy or inability to follow instructions * Lack of internet access or inability to use online applications

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Facial aging

Contacts and locations

Locations

  • Kasr El Aini Hospital, Cairo, English (English)

    Cairo, Cairo Governorate, 11511, Egypt

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