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Botox battle: which injection site lifts drooping mouth corners best?

NCT ID NCT07646886

Symptom relief Sponsor: Peking University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jul 08, 2026 · Updated 4 times

Summary

This study compares two injection sites for Botox to treat drooping mouth corners, a common sign of aging. 266 adults aged 18-60 will receive a single injection either in the upper or lower part of a specific mouth muscle. The goal is to see which spot works better and safer, and to create standard guidelines for doctors.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Botulinum toxin type A (Botox)
What this could lead to
If successful, this trial could establish the best injection site for treating drooping mouth corners with Botox, providing clear guidelines for doctors.
What could go wrong
This is a phase 4 trial, so the treatment is already approved for other uses. However, results may vary by individual, and there is a risk of temporary weakness in nearby muscles or asymmetry.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 266 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18 to 60 years, any gender * Meet the diagnostic criteria for oral commissure ptosis: bilateral oral commissure ptosis angle (angle between the oral commissure point and the horizontal line of the ipsilateral vermilion border) \> 1° at rest * Have clear aesthetic demand for oral commissure ptosis improvement and can complete full-cycle follow-up * No redness, swelling, ulcer, scar, deformity or active infection in the perioral and mental regions * Have not participated in other interventional clinical trials within 3 months before enrollment Exclusion Criteria: * Hypersensitivity to botulinum toxin type A, lidocaine or excipients of injection preparations; or contraindications to botulinum toxin injection (myasthenia gravis, Lambert-Eaton syndrome, motor neuron disease, severe liver and kidney dysfunction, coagulation disorders, uncontrolled autoimmune diseases, malignant tumors) * History of mid-lower facial botulinum toxin type A injection, soft tissue filling, laser/radiofrequency rejuvenation, perioral surgery or orthognathic treatment within 6 months before enrollment * Planned perioral treatment within 6 months after enrollment that may affect efficacy evaluation * Pregnant or lactating women, or those planning to become pregnant within 6 months * Acquired oral commissure ptosis caused by facial nerve palsy/sequelae, perioral scar traction, severe jaw deformity or severe alveolar bone resorption * Severe facial asymmetry (difference in bilateral oral commissure ptosis angle \> 2°) * History of botulinum toxin allergy or severe adverse reactions after previous botulinum toxin injection * Currently using aminoglycoside antibiotics, quinine, calcium channel blockers, anticoagulants or other drugs that may affect botulinum toxin efficacy or increase bleeding risk and cannot discontinue * History of mental illness, drug/alcohol abuse, or poor compliance unable to complete follow-up * Other conditions deemed unsuitable for enrollment by the investigator

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Facial aging Melomental folds Oral commissure ptosis

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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