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Face-Lift without surgery? fat transfer may turn back the clock on wrinkles

NCT ID NCT07737639

Symptom relief Sponsor: L'Oreal Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study tests whether transferring a woman's own fat to her face can improve skin quality and reduce signs of aging like wrinkles, sagging, and uneven texture. Healthy women over 30 who choose to have the procedure will be followed for six months with skin measurements and self-assessments. The goal is to see how well lipofilling works and whether certain biological markers in the fat predict better results.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
autologous fat transfer (lipofilling)
What this could lead to
If it works, this could point toward a natural, minimally invasive way to rejuvenate aging facial skin using a person's own fat.
What could go wrong
This is a very small, early study with only 15 participants and no comparison group, so results may not apply widely. The procedure also carries typical surgical risks like swelling, bruising, or uneven results.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

15 people

The number who actually took part.

Started

Jan 2021

Finished

Sep 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of individuals seeking aesthetic facial rejuvenation at the Hospices Civils de Lyon (HCL) in Lyon, France. Participants are recruited directly from the standard clinical practice of the principal investigator. A defining characteristic of this cohort is that all individuals have independently elected, and are already scheduled, to undergo an autologous facial fat transfer (lipofilling) procedure for anti-aging purposes prior to and independent of study enrollment. The study observes the outcomes of this pre-planned surgical intervention, with subsequent clinical and instrumental follow-up evaluations.

Ages

30 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Female patient volunteers 2. Over the age of 30 3. Who had decided to have adipose tissue injections and declared eligible to this intervention 4. Nonsmoker or less than 5 cigarettes per day 5. Informed about the study objectives and procedures, and able to understand them 6. Willing and able to fulfil the study requirements and schedule 7. Able to give their written informed consent 8. French subjects recruited must be affiliated to the French social security system. Exclusion Criteria: 1. Having participated within the 30 days before inclusion or currently participating in another clinical study. 2. Females in pregnancy or nursing 3. Dermatological disorder affecting the investigational areas (like severe acne, rosacea eczema, atopy, psoriasis, seborrheic dermatitis) that may interfere with the study conduct or the study results in the opinion of the Investigator, 4. History of skin cancer or auto-immune disease, 5. History of allergy, hypersensitivity, or any serious reaction to any medicinal or cosmetic product, 6. Any concomitant medical condition that may interfere with the study conduct in the opinion of the investigator (diabetes, HIV+, hepatitis B and C…) 7. Surgical procedure to the face (face lift) 8. Cosmetic procedures: filler injection, botulinum toxin injection, laser to the face within the past 4 months 9. Actual or past use of systemic or topic drugs, that would interfere with assessment and/or investigational treatments and affect study results in the opinion of the investigator

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Facial aging

Contacts and locations

Locations

  • L'Oréal

    Aulnay-sous-Bois, 93600, France

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