Could a simple pill boost knee replacement recovery?

NCT ID NCT07494032

Symptom relief Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking tranexamic acid pills for a week after knee replacement surgery helps people recover better. 350 adults having their first knee replacement will receive either the drug or a placebo. Researchers will track pain, stiffness, and function for up to 2 years to see if the drug makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: tranexamic acid
What this could lead to: If it works, this could mean a simple, cheap pill after knee replacement leads to better pain relief and faster recovery.
What could go wrong: This is a small, early-stage trial. The drug may not improve outcomes more than placebo, and side effects like blood clots are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 350 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

May 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients are candidates for elective primary total knee arthroplasty. * Patients ≥18 years of age * Patients have been medically evaluated and scheduled for primary total knee arthroplasty. * Patients undergo primary total knee arthroplasty with spinal anesthesia * Patients receive 1g IV TXA prior to incision and 1g IV TXA at closure * Patients are prescribed aspirin 81mg twice a day for postoperative VTE prophylaxis Exclusion Criteria: * Patients with an allergy to TXA * Patients taking a preoperative anticoagulant other than aspirin * Patients with a history of VTE * Patients with chronic kidney disease * Patients with active malignancy * Current use of combined hormonal contraception (pill, patch, or ring) * eGFR \<60 mL/min/1.73 m² or other clinically significant renal impairment * Use of Factor IX complex concentrates, anti-inhibitor coagulant concentrates, or all-trans retinoic acid (tretinoin) * Anticipated need for tissue plasminogen activator (tPA) during the 7-day dosing period * Individuals who are pregnant or breastfeeding, have a positive pre operative pregnancy test, or plan pregnancy during the 7 day dosing window. Women of childbearing potential must have a negative pre operative pregnancy test and use effective contraception through postoperative day . Individuals who are on hormonal contraceptives or hormone replacement therapies, with the exception of Progestin, are to be excluded.

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Conditions

The condition(s) this trial relates to.

arthropathy osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee arthropathy

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Could a simple pill boost knee replacement recovery?

What the study statuses mean