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Stroke drug combo shows promise in restoring blood flow before clot removal

NCT ID NCT05203224

First seen May 09, 2026 · Last updated May 22, 2026 · Updated 4 times

Summary

This study tested whether adding dornase alfa to standard clot-busting drugs helps restore blood flow faster in people with severe stroke caused by a large artery blockage. About 330 adults who arrived at the hospital within 4.5 hours of symptoms and were eligible for clot removal participated. The goal was to see if the drug could improve blood flow before the clot removal procedure, without causing bleeding in the brain.

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Contacts and locations

Locations

  • Princess Alexandra Hospital

    Brisbane, Queensland, 4102, Australia

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000, Australia

  • Royal Melbourne Hospital

    Melbourne, Victoria, 3050, Australia

Conditions

Explore the condition pages connected to this study.