Enzyme cocktail may boost stroke recovery before clot removal

NCT ID NCT05203224

First seen May 09, 2026 · Last updated May 14, 2026 · Updated 2 times

Summary

This study tested adding dornase alfa, an enzyme that breaks up DNA in blood clots, to standard clot-busting drugs and mechanical clot removal in 330 adults with severe ischemic stroke. The goal was to see if the combination could restore blood flow more quickly before the surgical procedure. The trial aimed to find the best dose for a future larger study.

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Contacts and locations

Locations

  • Princess Alexandra Hospital

    Brisbane, Queensland, 4102, Australia

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000, Australia

  • Royal Melbourne Hospital

    Melbourne, Victoria, 3050, Australia

Conditions

Explore the condition pages connected to this study.