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Exercise or pills? study pits walking against metformin for prediabetes

NCT ID NCT07061496

Disease control Sponsor: Asad Ullah Jan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study compared moderate exercise (like brisk walking) with the drug metformin in 226 adults with prediabetes. Participants were randomly assigned to either exercise for 30-45 minutes, 5 days a week, or take metformin twice daily for 12 weeks. Researchers measured changes in blood sugar (HbA1c) and weight to see which approach worked better in a real-world, low-resource community setting.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
metformin
What this could lead to
If it works, this could show that exercise is as good as or better than metformin for controlling blood sugar in prediabetes, offering a low-cost option.
What could go wrong
This is a small, completed trial in one community, so results may not apply broadly. Also, open-label design means participants knew their group, which can bias results.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

226 people

The number who actually took part.

Started

Aug 2025

Finished

Mar 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 59 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 59 years * Diagnosed with prediabetes based on ADA criteria (FPG: 100-125 mg/dL or HbA1c: 5.7-6.4%) * Stable HbA1c levels (no significant fluctuation in the last 3 months) * Body Mass Index (BMI) less than 30 kg/m² * Willing and able to provide written informed consent * Willing to participate in the assigned intervention (exercise or metformin) for 12 weeks * Residing within the community and able to attend scheduled follow-ups Exclusion Criteria: * Age 60 years or older * Diagnosis of Type 2 Diabetes Mellitus (T2DM) or use of anti-diabetic medications * Family history of diabetes in first-degree relatives (parent or sibling) * Known cardiovascular, renal, or hepatic disease * Pregnancy or lactation * Physical disability or limitation that would interfere with performing moderate-intensity exercise * Uncontrolled hypertension (SBP ≥ 160 mmHg or DBP ≥ 100 mmHg) * Known allergy or contraindication to metformin * Alcohol or substance abuse

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Conditions

The condition(s) this trial relates to.

glucose intolerance Motor Activity prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pre-diabetes Pre-diabetic

Contacts and locations

Locations

  • Department of Preventive Medicine, Combined Military Hospital Nowshera

    Nowshera, 25770, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.