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Single dose of esketamine may lift mood after heart surgery

NCT ID NCT06608030

Symptom relief Sponsor: Chinese PLA General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a single low dose of esketamine, given during anesthesia, could reduce anxiety and depression in 142 adults undergoing heart valve surgery. Participants were randomly assigned to receive either esketamine or a placebo (saline). The researchers measured mood using standard questionnaires before and after surgery. The goal was to see if this simple addition could improve emotional recovery after a major operation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
esketamine
What this could lead to
If it works, this could offer a simple way to ease anxiety and depression after heart surgery.
What could go wrong
This is a small, completed trial with no phase designation, so results may not be conclusive or widely applicable. Esketamine can cause side effects like dizziness or dissociation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

142 people

The number who actually took part.

Started

Sep 2024

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18 years old, male or female 2. Patients undergoing heart valve surgery 3. Patients with ASA grade 1 to 4 4. BMI between 18-30 kg/m² 5. Able to participate in neuropsychological testing and receive follow-up visits 6. Clearly understand and voluntarily agree to participate in the study and sign the informed consent form Exclusion Criteria: 1. Patients with significant preoperative neuro-psychiatric disease and cognitive impairment 2. Intellectual disability or a MiniMental State Examination (MMSE) score \<24, or a speech disorder that may compromise their ability to undergo preoperative assessments 3. History of psychoactive drug abuse 5\. Preoperative combined severe hepatic insufficiency or renal insufficiency 6. Any contraindications to ketamine or esketamine, such as refractory hypertension or hyperthyroidism

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac surgery Depression, anxiety S-ketamine

Contacts and locations

Locations

  • Beijing Tiantan Hospital

    Beijing, Beijing Municipality, China

  • First Medical center of Chinese PLA General Hospital

    Beijing, Beijing Municipality, China, China

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