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Can a common blood thinner protect critically ill kids from catheter clots?

NCT ID NCT04924322

Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether enoxaparin, a blood thinner, can prevent blood clots caused by central venous catheters in critically ill children. Researchers will enroll 258 children up to 17 years old and adjust the dose based on age. The goal is to see if age affects how well the drug works, while monitoring for bleeding risks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Enoxaparin (a blood thinner, also known as Lovenox or Clexane)
What this could lead to
If successful, this could provide a safer, age-appropriate way to prevent dangerous blood clots from catheters in critically ill children, reducing complications.
What could go wrong
This is a mid-stage trial with 258 participants, so results may not apply to all children. Enoxaparin carries a risk of bleeding, which could be serious in critically ill patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 258 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2022

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Up to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria 1. \>36 weeks corrected gestational to \<17 years old 2. \<24 hours after insertion of an untunneled CVC 3. CVC inserted in the internal jugular or femoral vein Exclusion criteria 1. Radiologic diagnosis of CADVT in the site of insertion in prior 6 weeks 2. Currently receiving an antithrombotic agent, e.g., LMWH, UFH, warfarin and aspirin, but not UFH at dose to maintain patency of a vascular catheter 3. Presence of clinically relevant bleeding, i.e., hemoglobin decreased ≥2 g/dl in 24 hours, required medical or surgical intervention to restore hemostasis, or in the retroperitoneum, pulmonary, intracranial or central nervous system, in the prior 60 days 4. Surgery in the prior 7 days 5. Major trauma in the prior 7 days 6. Presence of coagulopathy, i.e., INR \>2.0, aPTT \>50 seconds or platelet count \<50 x 10\^3/mcL 7. Presence of renal failure, i.e., creatinine clearance \<30 mL/min/1.73 m2 8. Known hypersensitivity to heparin or pork products 9. Laboratory confirmed HIT 10. Current pregnancy or lactation 11. Presence of an epidural catheter 12. Limitation of care 13. Previous enrollment in the CRETE Studies

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Conditions

The condition(s) this trial relates to.

Critical Illness Hemorrhage venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Deep venous thrombosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    20 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Arkansas Children's Hospital

    RECRUITING

    Little Rock, Arkansas, 72202, United States

  • Children's Hospital Colorado

    RECRUITING

    Aurora, Colorado, 80045, United States

  • Children's Hospital St. Louis

    RECRUITING

    St Louis, Missouri, 63110, United States

  • Children's Hospital Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Children's Hospital of Illinois at OSF Saint Francis Medical Center

    RECRUITING

    Peoria, Illinois, 61637, United States

  • Children's Hospital of Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Hospital of Richmond

    WITHDRAWN

    Richmond, Virginia, 23219, United States

  • Children's of Alabama

    RECRUITING

    Birmingham, Alabama, 35233, United States

  • Dell Children's Medical Canter

    RECRUITING

    Austin, Texas, 78723, United States

  • Golisano Children's Hospital

    RECRUITING

    Rochester, New York, 14642, United States

  • Hassenfeld Children's Hospital

    RECRUITING

    New York, New York, 10016, United States

  • Johns Hopkins All Children's

    RECRUITING

    St. Petersburg, Florida, 33701, United States

  • Maria Fareri Children's Hospital

    RECRUITING

    Valhalla, New York, 10595, United States

  • Nationwide Children's Hospital

    WITHDRAWN

    Columbus, Ohio, 43205, United States

  • New York Presbyterian Hospital

    RECRUITING

    New York, New York, 10065, United States

  • Penn State Hershey Children's Hospital

    RECRUITING

    Hershey, Pennsylvania, 17033, United States

  • Stead Family Children's Hospital

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • UH Rainbow Babies & Children's Hospital

    RECRUITING

    Cleveland, Ohio, 44106, United States

  • UTSW Medical Center; Children's Medical Center of Dallas

    RECRUITING

    Dallas, Texas, 75235, United States

  • University of Florida -UF Health

    RECRUITING

    Gainesville, Florida, 32610, United States

  • University of Oklahoma

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • Yale-New Haven Children's Hospital

    RECRUITING

    New Haven, Connecticut, 06520, United States

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