Can a simple EEG replace costly MRI scans for anorexia research?
NCT ID NCT04583774
First seen Jun 26, 2026 · Last updated Aug 04, 2026 · Updated 2 times
Summary
This study explores whether electroencephalography (EEG), a cheaper and more accessible brain monitoring technique, can reliably measure how the brain processes rewards in adolescents with anorexia nervosa. Researchers will compare EEG results with those from functional MRI (fMRI) in 47 girls aged 11-17. If EEG works, it could enable larger studies to understand and eventually treat anorexia more effectively.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could make it easier and cheaper to study brain reward processing in anorexia nervosa, potentially leading to better treatments.
- What could go wrong
- This is a small, early feasibility study with only 47 participants. It is not testing a treatment, so it may not directly help patients. The EEG method may not work as well as hoped.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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47 people
The number who actually took part.
- Started
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Feb 2021
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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11 to 17 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Healthy Controls * Females ages 11 - 17 years * Healthy body weight between 90 and 110 % average body weight. * Edinburgh Handedness Inventory Revised (EHI-R) LQ\* score \> +200 * English is primary language spoken Restricting Type Anorexia Nervosa * Females ages 11 - 17 years * Diagnostic criteria. Current diagnosis of AN, including being underweight below 17.5 body mass index (BMI, kg/m2), will have a severe fear of weight gain, body image distortion and absence of the menstrual cycle over three consecutive months (if applicable). * First 1-2 weeks in treatment at The University of California San Diego Eating Disorders Center for Treatment and Research or Rady Children's Hospital San Diego Medical Behavioral Unit. * Restricting subtype, that is without binge/purge behaviors * Edinburgh Handedness Inventory Revised (EHI-R) LQ\* score \> +200 * English is primary language spoken Exclusion Criteria: Healthy Controls * Current pregnancy or breast feeding within last 3 months * Illiterate/Blind individuals * First degree relative with current or past eating disorder * Current Medications other than BCP or IUD * Past or present Axis I psychiatric disorder including substance or alcohol use disorder as determined through PI interview and MINI-Kid clinical interview * Major Medical illness (as determined through medical history in bioscreen and PI interview) such as: * Conditions that are life threatening: * cancer * heart disease * stroke * HIV/AIDS * Seizure Disorders * Conditions that are life threatening Conditions that cause serious disability without necessarily being life threatening: * stroke * closed head or spinal cord injuries * mental retardation * congenital malformations. * Conditions that cause significant pain or discomfort that can cause serious interruptions to life activities: * severe allergies * migraine * arthritis * sickle cell disease * Conditions that require major commitments of time and effort from care-givers for a substantial period of time: * mobility disorders * blindness * Alzheimer's disease and other dementias * chronic obstructive pulmonary disease * paraplegia or quadriplegia * Down's syndrome * depression * Conditions that may require frequent monitoring: * diabetes * conditions requiring anticoagulation treatment * severe asthma * severe allergies * schizophrenia and other psychotic illnesses. * Conditions that predict or are associated with severe consequences: * hypertension (associated with heart disease) * depression (associated with suicide) * diabetes (associated with blindness, kidney failure) * alcohol and other substance abuse (associated with intentional and unintentional injuries). * Recent history of suspected substance abuse or a lifetime history of psychostimulant abuse and/or dependence * Metal implants or braces (as determined through fMRI screening form) Anorexia Nervosa * Pregnancy or breast feeding within last 3 months * Lifetime history of bipolar disorder or psychosis * Illiterate/Blind individuals * Use of an anti-psychotic or other dopamine acting medication including stimulants within the past week at time of MRI * Recent history of substance abuse or dependence (within the last month) * Major Medical illness (as determined through medical history in bioscreen and PI interview) such as: * Conditions that are life threatening: * cancer * heart disease * stroke * HIV/AIDS * Seizure Disorders * Conditions that are life threatening Conditions that cause serious disability without necessarily being life threatening: * stroke * closed head or spinal cord injuries * mental retardation * congenital malformations. * Conditions that cause significant pain or discomfort that can cause serious interruptions to life activities: * severe allergies * migraine * arthritis * sickle cell disease * Conditions that require major commitments of time and effort from care-givers for a substantial period of time: * mobility disorders * blindness * Alzheimer's disease and other dementias * chronic obstructive pulmonary disease * paraplegia or quadriplegia * Down's syndrome * Conditions that may require frequent monitoring: * diabetes * conditions requiring anticoagulation treatment * severe asthma * severe allergies * schizophrenia and other psychotic illnesses. * Conditions that predict or are associated with severe consequences: * hypertension (associated with heart disease) * diabetes (associated with blindness, kidney failure) * alcohol and other substance abuse (associated with intentional and unintentional injuries) within the last month * Metal implants or braces (as determined through fMRI screening form)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of California San Diego
San Diego, California, 92121, United States
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Other studies related to the condition(s) this trial covers.
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