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Small study seeks best dose of anesthesia booster for joint surgery

NCT ID NCT07144215

Knowledge-focused Sponsor: Indonesia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed study with 40 adults undergoing hip or knee surgery aimed to find the most effective dose of dexmedetomidine when added to standard spinal anesthesia. Researchers tested doses from 3 to 6 micrograms to see which one made the numbness last at least 200 minutes. The goal is to improve pain control during and after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine
What this could lead to
If successful, this could help doctors choose the right dose of dexmedetomidine to make spinal anesthesia last longer during hip and knee surgery.
What could go wrong
This is a small, early-phase study with only 40 participants, so results may not apply to everyone. The main risks include low blood pressure, slow heart rate, and nausea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Feb 2025

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-60 years old * Pelvic or knee surgery patient with American Society of Anesthesiologists physical status I - III with epidural spinal anesthesia * Body mass index 18-35 kg/m2 * Body height 150-180 cm * Willing to become a research participant Exclusion Criteria: * Have a history of allergy to bupivacaine or dexmedetomidine * Have sensory or motoric disabilities in the lower extremity contralateral to the surgery area * Have a history of congestive heart failure and/or heart rhythm disorder * Have regional anesthesia contraindication

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee surgery Pelvic surgery Spinal aneshtesia

Contacts and locations

Locations

  • RSUPN Cipto Mangunkusumo

    Jakarta Pusat, Jakarta Special Capital Region, 10430, Indonesia

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