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Can a simple drug stop nausea during emergency C-Sections?

NCT ID NCT07740577

Disease control Sponsor: Sanliurfa Education and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Aug 19, 2026 · Updated 2 times

Summary

This trial tests whether giving a preventive anti-nausea drug before an emergency cesarean section under spinal anesthesia can reduce nausea, retching, or vomiting during surgery. It focuses on women who have not fasted, which may increase the risk of these symptoms. The study compares two common medications, ondansetron and metoclopramide, to see which works better. The goal is to improve comfort and safety for mothers during this procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ondansetron and metoclopramide
What this could lead to
If effective, this could help standardize antiemetic use during emergency cesareans, improving maternal comfort and reducing complications.
What could go wrong
The trial is relatively small and focuses on a specific population, so results may not apply broadly. Both drugs have known side effects, and the study is not designed to prove long-term benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pregnant women scheduled for emergency cesarean delivery under spinal anesthesia * Non-fasted (full-stomach) parturients * American Society of Anesthesiologists (ASA) physical status I-II * Age ≥ 18 years * Singleton pregnancy * Ability to provide written informed consent Exclusion Criteria: * ASA physical status III or higher * Refusal to participate * Elective cesarean delivery (non-emergency cases) * Preoperative antiemetic use within 24 hours before surgery * Known allergy or contraindication to study drugs (ondansetron or metoclopramide) * Pre-existing gastrointestinal disorders (e.g., severe GERD, gastroparesis, bowel obstruction) * Psychiatric illness or current use of psychotropic medications * Preoperative anemia (as defined by institutional threshold, e.g., Hb \< 10 g/dL) * Intraoperative conversion to general anesthesia * Massive intraoperative hemorrhage (\>1000-1500 mL or requiring transfusion, depending on your protocol definition) * Intraoperative administration of additional sedative or antiemetic agents outside study protocol * Multiple gestation pregnancies

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Conditions

The condition(s) this trial relates to.

Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Antiemetic therapy Ceserean section Intraoperative nausea-retching-vomiting episodes Metoclopramide Ondansetron Spinal aneshtesia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sanliurfa Education and Research Hospital

    RECRUITING

    Sanliurfa, Eyyübiye, 63040, Turkey (Türkiye)

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