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Downhill treadmill training with electric zaps may help spinal injury patients walk again

NCT ID NCT05337982

Disease control Sponsor: Ohio State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new rehabilitation program for people with recent spinal cord injuries (within 1-5 months). Participants walk on a downhill treadmill while receiving electrical stimulation to their leg and trunk muscles. The goal is to improve walking and movement. Researchers will also check blood and spinal fluid for biomarkers to find the best time to start training. The study includes 49 participants and compares the new training to standard rehabilitation alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
downhill eccentric treadmill training with electrical muscle stimulation
What this could lead to
If successful, this could point toward a more effective rehabilitation approach to improve walking and function after spinal cord injury.
What could go wrong
This is an early-stage study with only 49 participants, so results may not apply to everyone. The training is intensive and may not work for all injury levels.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 49 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

INCLUSION CRITERIA: SCI participants WITHIN 1-5 MONTHS OF THEIR INJURY: * Discharged from inpatient rehabilitation; * AIS A-D at neurologic level C1-T10; * 18-85 years old. Healthy controls: * Adults 18-85 years old; * no recent major musculoskeletal injury; * no recent surgery. EXCLUSION CRITERIA: SCI participants: * Use of botox in the past 3 months that reduces skeletal muscle function; * other neurologic conditions (i.e. brain injury, stroke, HIV); * current cancer diagnosis; * active deep vein thrombosis and anti-coagulation therapy; * skin wounds in regions that interfere with harness, stimulation pads or hand placement needed for training. * pregnancy; * ventilator-dependence; * cognitive conditions that preclude providing informed consent. * Implanted medical devices that are contraindicated for electrical stimulation or MRI \*(If SCI participants have conditions contraindicated for MRI they may still participate in the remainder of study activities without myelin status as an outcome measure. SCI is a rare condition therefore this is necessary in order to achieve the required sample size.) Healthy controls: * Implanted medical devices that are contraindicated for MRI (MRI participants only); * neurologic conditions (i.e. brain injury, stroke, HIV); * current cancer diagnosis; * clotting disorders requiring anti-coagulation therapy; * inflammatory conditions like arthritis, ulcerative colitis, lupus, etc; * pregnancy; * fear of needles; * claustrophobia; * cognitive conditions that preclude providing informed consent.

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Conditions

The condition(s) this trial relates to.

spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy Spinal cord injuries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Ohio State University

    RECRUITING

    Columbus, Ohio, 43210, United States

  • University of British Columbia

    RECRUITING

    Vancouver, Canada

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