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Blood-Derived filler could replace donor bone in dental implants

NCT ID NCT07445776

Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two materials for filling the gap around a dental implant placed right after tooth removal: e-PRF (made from the patient's own blood) and allograft (donor bone). Twenty-eight patients with damaged front teeth received one of the two fillers. The main goal was to see how stable the implant became and how much bone was lost around it. The results could help dentists choose a simpler, natural option for implant success.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
e-PRF (extended platelet-rich fibrin) and allograft (donor bone material)
What this could lead to
If e-PRF works as well as allograft, it could offer a simpler, cheaper option for filling gaps around dental implants using the patient's own blood products.
What could go wrong
This is a small, completed study with only 28 patients, so results may not apply to everyone. e-PRF is still experimental for this use and may not be as effective as standard allograft.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

28 people

The number who actually took part.

Started

May 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with badly destructed teeth due to trauma or caries. 2. Patients willing to complete the study follow up intervals. 3. Patients with good oral hygiene. 4. Adequate inter-arch space that can accommodate implant abutment and future restoration. 5. No gender preference in selection of the patients. Exclusion Criteria: 1. Patients with systemic diseases that absolutely contraindicate dental implant placement. 2. Patients with parafunctional habits (bruxism and clenching). 3. Heavy smokers (i.e. More than 20 cigarettes/day)34 and alcoholism. 4. Presence of local infection or lesions at the proposed area for dental implant. 5. Pregnancy. 6. Patient taking drugs that could affect bone healing process as immunosuppressive drugs and bisphosphonates. 7. Patients with bad oral hygiene and untreated periodontal disease 8. Uncooperative patients

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gap filling with allograft Gap filling with E-PRF Immediate implant placement

Contacts and locations

Locations

  • Faculty of Dentistry, Mansoura University

    Al Mansurah, 002, Egypt

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