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Double shock may save more cardiac arrest victims

NCT ID NCT07174986

Disease control Sponsor: Gabriel Riva Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial tests whether using two defibrillators in sequence, instead of the standard single defibrillator, can improve survival in people whose hearts are in a shockable rhythm but don't respond to the first shock. About 916 adults with out-of-hospital cardiac arrest will be randomly assigned to either the double-shock approach or standard care. The main goal is to see if more patients are alive at 30 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Double sequential defibrillation (using two defibrillators)
What this could lead to
If it works, this could become a new standard emergency procedure to save more lives in cardiac arrest.
What could go wrong
This is an early combined Phase 2/3 trial, so results are uncertain. The benefit seen in a prior study may not hold in this broader group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 916 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * OHCA patients with VT/VF at first rhythm analysis and at least one defibrillation performed in standard (A-L) position Exclusion Criteria: * Age \< 18 years * Obvious pregnancy * Known preexisting Do Not Attempt Resuscitation order

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Conditions

The condition(s) this trial relates to.

acrocallosal syndrome cardiac arrest Death, Sudden Out-of-Hospital Cardiac Arrest ventricular fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACLS CPR Defibrillation Out-of-hospital cardiac arrest Sudden death Ventricular fibrillation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    14 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • ARREST (AmsteRdam REsuscitation STudies)

    NOT_YET_RECRUITING

    Amsterdam, Netherlands

  • Ambulanshelikoptern (HEMS) Västra Götalandsregionen

    RECRUITING

    Kungälv, Västra Götaland County, 442 83, Sweden

  • Ambulanssjukvården Region Värmland

    RECRUITING

    Karlstad, Värmland County, 65230, Sweden

  • Ambulanssjukvården Skaraborgs Sjukhus, Västra Götalandsregionen (SKAS)

    RECRUITING

    Skövde, Sweden

  • Ambulanssjukvården, Region Halland

    RECRUITING

    Halmstad, Halland County, Sweden

  • Centro de Emergencias 061 Andalucía

    NOT_YET_RECRUITING

    Málaga, Andalusia, 29560, Spain

  • Emergency medical services NU-Sjukvården, Region Västra Götaland

    RECRUITING

    Trollhättan, 461 85, Sweden

  • Emergency medical services, Södra Älvsborgs Sjukhus, Region Västra Götaland

    RECRUITING

    Borås, 501 82, Sweden

  • Médico Emergencias Osakidetza EMERGENTZIAK

    NOT_YET_RECRUITING

    Bilbao, Baque Country, 48004, Spain

  • Prehospital Intensive Care Unit (PIV) AnOPIVA Östra Sjukhuset/SU

    RECRUITING

    Gothenburg, Sweden

  • SUMMA 112 Emergency medical services

    NOT_YET_RECRUITING

    Madrid, Madrid, 28045, Spain

  • Shalgrenska University Hospital

    RECRUITING

    Gothenburg, Sweden

  • Sistema de Emergencias Medicas de Catalunya

    NOT_YET_RECRUITING

    Barcelona, Catalonia, 08908, Spain

  • Sjukvården i väster

    RECRUITING

    Alingsås, Sweden

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