Pain-Free shots? study tests if preservative is the culprit
NCT ID NCT07600814
First seen May 29, 2026
Summary
This early-phase trial investigates whether m-Cresol, a preservative used in many injectable medications like insulin, causes pain at the injection site. Eighteen healthy volunteers will receive three injections in their belly: one with a low concentration of m-Cresol, one with a higher concentration, and one without the preservative. They will rate their pain every 5 seconds until it stops. The goal is to see if m-Cresol is a major source of injection pain, which could lead to more comfortable drug formulations.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
m-Cresol (a preservative used in injectable medications)
What this could lead to
If this trial shows m-Cresol causes pain, it could lead to reformulating common injectable drugs like insulin to be less painful, improving patient comfort and adherence.
What could go wrong
This is a very early, small study in only 18 healthy volunteers, not patients. The results may not reflect real-world use or lead to immediate changes in drug formulations.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.