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New filler takes on wrinkle rival in Head-to-Head trial

NCT ID NCT07412392

First seen Feb 18, 2026 · Last updated May 15, 2026 · Updated 14 times

Summary

This study compares a new injectable filler called DIOSHA S Lido with an existing filler, YOUTHFILL, for temporarily softening moderate to deep smile lines (nasolabial folds). About 60 adults aged 19 to 75 with symmetrical wrinkles will receive both treatments on opposite sides of their face to see if the new filler works just as well. The main goal is to measure wrinkle improvement after 24 weeks.

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