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New filler takes on wrinkle rival in Head-to-Head trial

NCT ID NCT07412392

Symptom relief Sponsor: Hyundae Meditech Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a new injectable filler (DIOSHA S Lido) with an existing one (YOUTHFILL) for temporarily softening moderate to deep smile lines. About 60 adults aged 19 to 75 with symmetrical wrinkles will receive both treatments in a blinded, matched-pairs design. The main goal is to see if the new filler works as well as the current option over 24 weeks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 19 to 75 years * Voluntarily provided written informed consent * Moderate to severe symmetrical nasolabial folds (WSRS score 3 or 4 on both sides) * Agree to discontinue other facial dermatologic treatments (e.g., fillers, botulinum toxin, laser) during the study * Able to understand instructions and comply with study procedures Exclusion Criteria: * Active facial skin disease, infection, or untreated scars in the treatment area * History of severe allergy or hypersensitivity to device components * Facial aesthetic or invasive procedures in the treatment area within 6 months prior to screening * Use of prohibited medications within required washout periods * Participation in another interventional clinical trial within 4 weeks prior to screening or during the study * Pregnancy, breastfeeding, or non-compliance with contraception requirements * Any condition deemed inappropriate by the investigator

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nasolabial folds, wrinkles

How to take part

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  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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