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New filler study aims to smooth smile lines for up to 2 years

NCT ID NCT07385053

Symptom relief Sponsor: Symatese Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how well and how long a hyaluronic acid filler called Estyme LIFT works for smile lines (nasolabial folds). About 96 adults who want this cosmetic treatment will get injections, with an optional touch-up after one month. Doctors will check safety and wrinkle improvement over up to 24 months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

96 people

The number who actually took part.

Started

Jun 2023

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subject seeking an aesthetic procedure defined by the correction of nasolabial folds with Estyme® LIFT (now marketed as ESTYME® FORM). * Subject who agreed to participate and have signed an informed consent. * Age: over 18 years old. * Subject being affiliated to a health social security system. Exclusion Criteria: * Patients with a known allergy to hyaluronic acid, lidocaine or amide local anesthetics. * Patients with porphyria. * Patients with an autoimmune disorder, or using an immunosuppressant medication. * Pregnant or breastfeeding women. * Patients with cutaneous disorders, inflammation or infection (herpes, acne, etc.) at the treatment siteor nearby. * Patients with bleeding disorders or in patients receiving thrombolytic or anticoagulant treatment. * Patients with an active or history of streptococcal diseases. * Children.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nasolabial folds, wrinkles

Contacts and locations

Locations

  • Cabinet médical

    Lyon, 69005, France

  • Centre Médical Saint Jean

    Arras, 62000, France

  • Palais de Flore

    Lyon, 69006, France

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