New blood clot pill could replace daily shots for joint replacement patients

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women between the ages of 18 and 80. * Patients scheduled for unilateral elective total hip or knee arthroplasty. * The patient's voluntary informed consent. * Negative pregnancy test result (for female patients with preserved reproductive potential). * Patients with reproductive potential should agree to use methods of contraception according to the protocol. Exclusion Criteria: * Surgery for an acute fracture (\<4 weeks). * Revision or extraction arthroplasty. * Septic arthritis. * The only lower limb. * Increased risk of thrombosis. * Active bleeding or increased risk of bleeding. * Current coagulopathy (patient's or his relative's) or congenital thrombophilia. * Collection of at least one volume unit of donated blood (≥ 450 ml) or blood transfusion during the previous 12 weeks. * Surgery or injury during the last 90 days. * Diseases of the digestive system that may disrupt the absorption of the study drug. * Significant cardiovascular diseases currently or within 6 months prior to screening. * Active liver or biliary tract diseases. * Creatinine clearance, calculated according to the Cockcroft-Gault formula, less than 30 ml/min. * Positive test result for HIV, syphilis, hepatitis B and C markers. * The development of trophic disorders of the lower extremities that are not amenable to drug treatment. * Any condition in which, in the opinion of the researcher, surgical intervention or the use of anticoagulants is contraindicated. * Body mass index is less than 18.5 or more than 40 kg/m2. * Body weight for women is less than 45 kg, for men less than 57 kg and above 130 kg for both. * Systolic blood pressure \> 180 mmHg and/or diastolic blood pressure \>110 mmHg. * Hemoglobin \< 105 g/l in women or \< 115 g/l in men. * Abnormal results aboratory parameters of the coagulation system (platelets, APTT, prothrombin time, INR) beyond the limits of normal values. * An increase in ALT or ACT ≥ 2 times from the upper limit of normal (ULN) or total bilirubin ≥ 1.5 times from ULN. * Hypersensitivity or contraindications to the administration of Dimolegin®, enoxaparin sodium, unfractionated heparin or warfarin. * The need for constant use of parenteral or oral anticoagulants. * The need for continuous use of antiplatelet drugs, which cannot be discontinued at least 4 days before the start of the investigational therapy. * Systemic therapy with drugs with strong inducers and inhibitors of CYP3A4 and P-glycoprotein, which cannot be discontinued at least 7 days before the start of the investigational therapy. * Pregnant or breast-feeding women. * Participation in another clinical trial currently or within 90 days prior to screening. * Affiliation to a research center, Sponsor, or contractual research organization. * Inability to read or write; unwillingness to understand and follow the procedures of the study protocol; non-compliance with the study therapy or procedures.