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New digital brace aims to fix underbite in kids without surgery

NCT ID NCT07376954

Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early study tests a custom-made digital dental device called the Digital Bonded Reverse Twin Block in 21 children aged 8-11 with a mild underbite. The device is designed to gently shift the jaw and teeth into better alignment. Researchers will measure changes in jaw position and dental health, and also ask about the children's quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Digital Bonded Reverse Twin Block (custom dental device)
What this could lead to
If it works, this could offer a more comfortable and effective way to correct underbite in children, potentially improving their smile and confidence.
What could go wrong
This is a very small, early-phase trial with only 21 participants. The device may not work for everyone, and long-term results are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 21 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

8 to 11 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients' age (8-11) years (CVM stages 2-3) * Mild class III skeletal pattern (Wits appraisal = 0 to -8) * Mixed dentition * Mild to moderate reverse overjet (-1 to -4) * Overbite (1-5) * Average or below average maxillary mandibular plane angle and lower facial height * Mild incisors compensations Exclusion Criteria: * Severe class III skeletal pattern * Long facial height * Bad oral hygiene * Systemic condition that may interfere with treatment * No premolars or deciduous molars

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Conditions

The condition(s) this trial relates to.

autosomal dominant prognathism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Skeletal class III malocclusion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Mansoura University

    Al Mansurah, Egypt

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