Could a daily supplement ease joint pain, fatigue, and sleep troubles in middle age?
NCT ID NCT07729930
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This trial tests whether a combination of dietary supplements, including creatine monohydrate, can improve common health complaints in healthy women aged 35 to 65. Over 8 weeks, participants take either the supplements or a placebo, and researchers measure changes in joint pain, fatigue, sleep quality, body composition, strength, and inflammation. The goal is to see if a simple supplement routine can help manage the physical and mental changes that often come with middle age.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- creatine monohydrate (a dietary supplement)
- What this could lead to
- If it works, this could point to a simple supplement routine that helps middle-aged women manage common age-related complaints like joint pain, fatigue, and sleep troubles.
- What could go wrong
- This is a small, early-stage trial with only 38 participants, so results may not apply broadly. Supplements can also cause digestive upset or other side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 38 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2026
- Expected to finish
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Nov 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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35 to 65 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Female * Aged 35-65 years old * Healthy, free from known disease * Non-smoker * BMI 18-30 kg/m2 * Classified as recreationally active (meet the WHO guidelines for physical activity: complete at least 150-300 minutes of moderate intensity activity or 75-150 minutes of vigorous intensity activity a week, plus muscle strengthening activities 2 or more days a week) OR sedentary (do not meet the minimum activity guidelines but do occasional and/or incidental physical activity, e.g., walking to work, household activities). Exclusion Criteria: * Currently have a musculoskeletal injury or diagnosed condition (CVD, osteoarthritis, diabetes, cancer, metabolic syndrome, uncontrolled hypertension, gastrointestinal disease, blood clotting disorder) * Regularly taking prescription medication initiated in the last 3 months or unstable * Have initiated hormone replacement therapy within the last 3 months or unstable * Have an allergy to ingredients in the supplements or standardised breakfast * Pregnant or breastfeeding, or any other contradictions to consuming the study supplements * Lost more than 10% of body mass in the past 6 months or plan on trying to lose body mass during trial period * Currently consuming the supplements being investigated and unwilling to stop * Any known cognitive or visual impairments limiting ability to perform cognitive tests * Unwilling to maintain current diet and physical activity levels and report any change in health status
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Loughborough University
RECRUITINGLoughborough, LE11 3TU, United Kingdom
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